In this paper the performance and the accuracy of artificial neural networks for the prediction of high-speed digital interconnects up to 100 GHz on printed circuit boards are analyzed and evaluated. The prediciton accuracy is evaluated both for scattering parameters in frequency domain as well as weighted power sums thereof. The interconnects considered all contain a backplane connected to a daughtercard, showing two via arrays each. Several parameter variations of the basic setup lead to a wide range of possible transmission and crosstalk parameters. Training data sets are obtained using physics-based via modeling up to 100 GHz. Approximately 7000 data sets were made available in total for this study. Neural networks are able to predict the overall link behavior.